其他產(chǎn)品及廠家

SARS-CoV-2 3CLpro-IN-17；化合物 SARS-CoV-2 3CLpro-IN-17SARS-CoV-2 3CLpro-IN-17
compound 3h, also known as sars-cov-2 3clpro-in-17, is a selective inhibitor of the sars-cov-2 3cl protease, demonstrating an ic50 of 0.322 μm [1].
更新時(shí)間:2025-09-05
SARS-CoV-2 3CLpro-IN-18；化合物 SARS-CoV-2 3CLpro-IN-18SARS-CoV-2 3CLpro-IN-18
sars-cov-2 3clpro-in-18 (compound 3c) is a covalent inhibitor of sars-cov-2 3clpro with an ic50 of 0.478 μm. it demonstrates inhibition of sars-cov-2 in vero e6 cells, with an ec50 of 2.499 μm, and exhibits low cytotoxicity (cc50 > 200 μm) [1].
更新時(shí)間:2025-09-05
E07 aptamer；化合物 E07 aptamerE07 aptamer
sars-cov-2 nsp14-in-4 (compound 12q) is a selective inhibitor of the sars-cov-2 nsp14 methyltransferase with an ic50 of 19 ± 2.5 nm. lacking a zwitterionic character, it can penetrate cells and is useful in research on covid-19 and its etiological agent, sars-cov-2 [1].
更新時(shí)間:2025-09-05
RUNX-IN-2；化合物 RUNX-IN-2RUNX-IN-2
runx-in-2 (compound conjugate 3) covalently attaches to runx-binding sequences, preventing runx proteins from associating with their targets, thereby inhibiting cancer cell proliferation and inducing p53-dependent apoptosis. furthermore, runx-in-2 suppresses tumor development in panc-1 xenograft mice and demonstrates notable alkylation efficiency and specificity [1].
更新時(shí)間:2025-09-05
WLB-89462；化合物 WLB-89462WLB-89462
wlb-89462 (compound 20c) is a selective σ2 receptor ligand with a k i of 13 nm, exhibiting neuroprotective properties and the ability to ameliorate aβ peptide-induced short-term memory impairment in rats. it possesses a favorable admet profile characterized by good solubility, absence of cyp inhibition, robust metabolic stability, high permeability, effective brain penetration, and substantial oral exposure in rodent models [1].
更新時(shí)間:2025-09-05
YCH1899；化合物 YCH1899YCH1899
ych1899, an orally active parp inhibitor, demonstrates potent inhibition of parp1/2 with an ic50 of less than 0.001 nm. it shows marked antiproliferative efficacy against olaparib-resistant (capan-1/op) and talazoparib-resistant (capan-1/tp) cells with ic50 values of 0.89 nm and 1.13 nm, respectively. moreover, ych1899 possesses favorable pharmacokinetic attributes in rats [1].
更新時(shí)間:2025-09-05
PIK5-12d；化合物 PIK5-12dPIK5-12d
pik5-12d, a potent protac pikfyve degrader (dc50: 1.48 nm), effectively induces cytoplasmic vacuolization and inhibits autophagic flux in various prostate cancer cell lines, concurrently halting their proliferation. this compound has demonstrated significant anti-tumor activity [1].
更新時(shí)間:2025-09-05
FD2157；化合物 FD2157FD2157
fd2157, a photosensitive pi3k inhibitor, exhibits inhibitory ic50 values of 43 nm for pi3kα, 83 nm for pi3kβ, 84 nm for pi3kγ, and 14 nm for pi3kδ. upon exposure to 365 nm uv light, fd2157 effectively inhibits cancer cell proliferation and induces apoptosis [1].
更新時(shí)間:2025-09-05
Methyl behenate山楂酸甲酯山楂酸甲酯|||山崳酸甲酯
methyl behenate is a natural compound, is an ester form of docosanoic acid .
更新時(shí)間:2025-09-05
Anti-inflammatory agent 56；化合物 Anti-inflammatory agent 56Anti-inflammatory agent 56
anti-inflammatory agent 56 (compound 9), a selective cox-2 inhibitor with an ic50 of 0.54 μm, exhibits anti-oxidant and anti-inflammatory properties by inhibiting oxidative stress-induced cell death and neuroinflammation through the suppression of keap1, cox-2, and inos. it also demonstrates low acute toxicity in mice with an ld50 of 1000 mg/kg [1].
更新時(shí)間:2025-09-05
nf-κb-in-11 (compound 3i) is an inhibitor of nf-κb, effectively blocking tnf-α-induced nf-κb pathway activation and the nuclear translocation of nf-κb. it also reduces the expression levels of phospho-ikk, iκbα, and nf-κb p65. demonstrating anti-inflammatory properties, nf-κb-in-11 mitigates dextran sulfate sodium-induced colitis in mice and exhibits a maximum tolerated dose (mtd) exceeding 1852 mg/kg in acute toxicity assays when administered orally (p.o.) [1].
更新時(shí)間:2025-09-05
DUB-IN-7；化合物 DUB-IN-7DUB-IN-7
dub-in-7 (compound 43), a deubiquitinating enzyme (dub) inhibitor, has utility in researching diseases driven by aberrant jak2 activity, including leukemia [1].
更新時(shí)間:2025-09-05
LUNA18；化合物 LUNA18LUNA18
luna18 is an orally active inhibitor targeting kras, exhibiting potent activity with an ic50 value of less than 2 nm against the kras g12d-sos mutation. it is utilized in cancer research [1].
更新時(shí)間:2025-09-05
HDAC-IN-64；化合物 HDAC-IN-64HDAC-IN-64
hdac-in-64 (compound 13), an hdac inhibitor, demonstrates potent inhibition of hdac4/5/6/7/9 with ic50 values of 24, 45, 85, 31, and 37 nm, respectively. it exhibits anti-proliferative and anti-migration effects on prostate cancer (pca) cells, specifically inhibiting the growth of lncap and rwpe-1 cells with gi50 values of 0.32 and 1.1 μm, respectively [1].
更新時(shí)間:2025-09-05
Antibacterial agent 153；化合物 Antibacterial agent 153Antibacterial agent 153
antibacterial agent 153 is a broad-spectrum agent that eradicates bacteria by targeting their cell membranes and is employed in research on bacterial infections [1].
更新時(shí)間:2025-09-05
SARS-CoV-2 3CLpro-IN-21；化合物 SARS-CoV-2 3CLpro-IN-21SARS-CoV-2 3CLpro-IN-21
sars-cov-2 3clpro-in-21 (compound d6) is an irreversible, covalent inhibitor of sars-cov-2 3cl pro, demonstrating potent inhibition with an ic50 of 0.03 μm. additionally, it exhibits inhibitory activity against sars-cov-1 3cl pro with an ic50 of 0.12 μm [1].
更新時(shí)間:2025-09-05
SARS-CoV-2-IN-58；化合物 SARS-CoV-2-IN-58SARS-CoV-2-IN-58
sars-cov-2-in-58 (compound 21h) serves as an antiviral agent targeting sars-cov-2, demonstrating efficacy with an ec50 of 18 μm. it specifically inhibits the sars-cov-2 main protease (mpro) with an ic50 value of 0.35 μm [1].
更新時(shí)間:2025-09-05
PPARγ-IN-2；化合物 PPARγ-IN-2PPARγ-IN-2
"pparγ-in-2 (compound 5a), a pparγ inhibitor, exhibits an ec50 of 0.106 μm in inhibiting tg accumulation in 3t3-l1 preadipocytes. furthermore, pparγ-in-2 counteracts obesity and associated metabolic syndrome induced by a high-fat cholesterol (hfc) diet and diminishes lipid accumulation in adipose tissue [1]."
更新時(shí)間:2025-09-05
PSEN1-IN-1；化合物 PSEN1-IN-1PSEN1-IN-1
psen1-in-1 (compound (+)-13b) functions as an inhibitor of psen1, displaying potent inhibition of the psen1-aph1a and psen1-aph1b complexes with respective ic50 values of 19 nm and 5.5 nm. this compound is utilized in alzheimer´s disease research [1].
更新時(shí)間:2025-09-05
Dazoxiben；達(dá)唑氧苯UK-37248；UK-37248|||達(dá)唑氧苯
dazoxiben (uk-37248) is a potent inhibitor of thromboxane (tx) synthase
更新時(shí)間:2025-09-05
PSEN1-IN-2；化合物 PSEN1-IN-2PSEN1-IN-2
psen1-in-2 (compound 13k) is a potent inhibitor of both psen1-aph1a and psen1-aph1b complexes, exhibiting ic50 values of 6.9 nm and 2.4 nm, respectively. as a psen1 inhibitor, it is utilized in alzheimer´s disease research [1].
更新時(shí)間:2025-09-05
CA inhibitor 2；化合物 CA inhibitor 2CA inhibitor 2
compound 4h is a potent carbonic anhydrase inhibitor with an ic50 value of 0.033 μm [1].
更新時(shí)間:2025-09-05
qsl-304；化合物 qsl-304qsl-304
qsl-304 is a dna gyrase b inhibitor that serves as an antibacterial agent, exhibiting an ic50 of 31.23 mg/ml against staphylococcus aureus sa-p2003 [1].
更新時(shí)間:2025-09-05
HDAC/CD13-IN-1；化合物 HDAC/CD13-IN-1HDAC/CD13-IN-1
hdac/cd13-in-1 (compound 12) is an inhibitor of both hdac and cd13, with ic50 values of 0.34 μm for hcd13, 0.53 μm for porcine cd13, and 0.03, 0.06, and 0.02 μm for hdac1, hdac2, and hdac3, respectively. this compound effectively suppresses the proliferation of mv4-11, k562, jeko-1, and hl60 cancer cells, with ic50 ranges between 0.25-2.04 μm, and also induces apoptosis in these cells. furthermore, hdac/cd13-in-1 demonstrates capabilities in hindering metastasis and invasion [1].
更新時(shí)間:2025-09-05
5-HT6R antagonist 1；化合物 5-HT6R antagonist 15-HT6R antagonist 1
compound 8 (5-ht6r antagonist 1), a 5-ht6r antagonist (k i : 5 nm), not only demonstrates inhibition of platelet aggregation and excellent metabolic stability but also reverses mk-801-induced memory impairments in rats, suggesting its utility in alzheimer´s disease (ad) research [1].
更新時(shí)間:2025-09-05
PI3Kα-IN-13；化合物 PI3Kα-IN-13PI3Kα-IN-13
pi3kα-in-13 (compound 18a), a pi3kα inhibitor with an ic50 of 2.5 nm, effectively induces apoptosis and hampers the proliferation of various cancer cell lines, exhibiting ic50 values of 0.75 μm (mcf-7), 3.79 μm (hct-116), 13.71 μm (mda-mb-231), and 9.85 μm (sw620). this compound also impedes tumor cell colony formation, migration, and invasion [1].
更新時(shí)間:2025-09-05
FGFR1 inhibitor-10；化合物 FGFR1 inhibitor-10FGFR1 inhibitor-10
fgfr1 inhibitor-10 (compound 4i), with an ic50 of 28 nm, effectively inhibits fgfr1 phosphorylation. this compound demonstrates anti-angiogenic and anti-invasion properties, as well as a significant anti-tumor effect [1].
更新時(shí)間:2025-09-05
TEAD-IN-6；化合物 TEAD-IN-6TEAD-IN-6
tead-in-6 (example 11-1) is a tead modulator that inhibits the yap1/taz-tead interaction, and has applications in cancer research [1].
更新時(shí)間:2025-09-05
FAK-IN-11；化合物 FAK-IN-11FAK-IN-11
fak-in-11 (compound 4l), a fak inhibitor, specifically targets the atp binding pocket of fak to prevent its phosphorylation. it exhibits cytotoxic effects on mda-mb-231 cells, achieving an ic50 value of 13.73 μm, and induces non-apoptotic cell death in these cells [1].
更新時(shí)間:2025-09-05
SIRT6-IN-3；化合物 SIRT6-IN-3SIRT6-IN-3
sirt6-in-3 (compound 8a), a selective sirt6 inhibitor (ic50 = 7.49 μm), impedes the proliferation of pancreatic ductal adenocarcinoma (pdac) cells and prompts apoptosis. it enhances the responsiveness of cancer cells to gemcitabine by obstructing the dna damage repair pathway, thus serving as a valuable tool in pancreatic cancer research [1].
更新時(shí)間:2025-09-05
Dipyrithione；雙吡啶硫酮Dipyrithione
dipyrithione appears to have novel cytotoxicity and potent broad-spectrum antitumor activity
更新時(shí)間:2025-09-05
FIKK9.1-IN-1；化合物 FIKK9.1-IN-1FIKK9.1-IN-1
fikk9.1-in-1 (compound 1), an antimalarial agent (ic50: 2.68 μg/ml), serves as a fikk9.1 inhibitor by interacting with the atp-binding residues within fikk9.1, thereby disrupting the parasite life cycle and resulting in parasite death [1].
更新時(shí)間:2025-09-05
AChE-IN-40；化合物 AChE-IN-40AChE-IN-40
ache-in-40 (compound 5c), with an inhibitory concentration 50 (ic50) of 120 nm, is an acetylcholinesterase (ache) inhibitor suitable for alzheimer´s disease research [1].
更新時(shí)間:2025-09-05
BChE-IN-19；化合物 BChE-IN-19BChE-IN-19
bche-in-19 (compound 7b), a para-substituted indone derivative, exhibits potent inhibitory activity against butyryl cholinesterase (bche) with an ic50 value of 0.04 μm. it enhances cholinergic neurotransmission and has potential therapeutic application in alzheimer´s disease [1].
更新時(shí)間:2025-09-05
NLRP3-IN-19；化合物 NLRP3-IN-19NLRP3-IN-19；NLRP3-IN-19
jt001 (nlrp3-in-19) is a potent, specific, and orally active nlrp3 inhibitor that impedes the assembly of the nlrp3 inflammasome. this action results in the suppression of cytokine release and prevention of pyroptosis. jt001 is utilized in research on nonalcoholic steatohepatitis and liver fibrosis [1].
更新時(shí)間:2025-09-05
JT001 sodium；化合物 JT001 sodiumNLRP3-IN-19 sodium；NLRP3-IN-19 sodium
jt001 (nlrp3-in-19) sodium is a potent, specific, and orally active nlrp3 inhibitor that impedes the assembly of the nlrp3 inflammasome, thus curbing cytokine release and averting pyroptosis. it is utilized in research focused on nonalcoholic steatohepatitis and liver fibrosis [1].
更新時(shí)間:2025-09-05
Casein kinase 1δ-IN-10；化合物 Casein kinase 1δ-IN-10Casein kinase 1δ-IN-10
casein kinase 1δ-in-10 is an inhibitor of casein kinase 1δ (ck1δ).
更新時(shí)間:2025-09-05
anti-TNBC agent-2；化合物 anti-TNBC agent-2anti-TNBC agent-2
anti-tnbc agent-2 (3j), a purine derivative, acts as an anti-triple negative breast cancer (tnbc) therapeutic. it promotes apoptosis in mda-mb-231 cells, while also inhibiting their migration and angiogenesis. moreover, anti-tnbc agent-2 suppresses tumor growth and metastasis, and downregulates ki67 and cd31 protein expression in tnbc xenograft models. it may be utilized for tnbc research [1].
更新時(shí)間:2025-09-05
7-Ethoxycoumarin；7-乙氧基香豆素7-Ethoxycoumarin
7-ethoxycoumarin, a typical human p450 substrate, is catalyzed by both wild-type and mutant forms of cyp102a1.
更新時(shí)間:2025-09-05
α-Glucosidase-IN-32；化合物 α-Glucosidase-IN-32α-Glucosidase-IN-32
α-glucosidase-in-32 (compound f26) is a reversible, noncompetitive inhibitor of α-glucosidase that is orally active and exhibits an ic50 of 3.07 μm. it forms a complex with α-glucosidase via hydrogen bonding and hydrophobic interactions, inducing conformational and secondary structure changes in the enzyme, thereby inhibiting its activity. this compound is utilized in diabetic disease research [1].
更新時(shí)間:2025-09-05
PI3K-IN-48；化合物 PI3K-IN-48PI3K-IN-48
pi3k-in-48, a pi3k inhibitor, exhibits an ic50 of 1.55 ± 0.18 μm in a549 cells, demonstrating its potency in this context. it induces g0/g1 phase arrest and cell apoptosis, while also down-regulating the expression of p-pi3k and p-akt. this compound is relevant for research into the treatment of human lung cancers [1].
更新時(shí)間:2025-09-05
Nrf2 activator-9；化合物 Nrf2 activator-9Nrf2 activator-9
nrf2 activator-9 (compound d-36) is an agent that mitigates oxidative stress by inhibiting the apoptosis of huvec cells induced by oxidized low-density lipoprotein (oxldl) and high glucose (hg). it also protects vascular endothelial cells (vec) from oxldl and hg-induced injury, offering potential therapeutic benefits for the prevention and treatment of atherosclerosis [1].
更新時(shí)間:2025-09-05
LP23；化合物 LP23LP23
lp23, a non-arylmethylamine pd-1/pd-l1 inhibitor (ic 50: 16.7 nm), exhibits anti-tumor activity through the restoration of immune cell function in hepg2/jurkat t cells and induction of hepg2 cell death. additionally, lp23 demonstrates in vivo efficacy in the b16-f10 tumor model (tgi=88.6% at 30 mg/kg) [1].
更新時(shí)間:2025-09-05
Cholicamideβ；化合物 CholicamideβCholicamideβ
cholicamideβ (compound 6), a self-assembling small molecule cancer vaccine adjuvant, forms low cytotoxicity virus-like particles and upon binding to peptide antigens, enhances dendritic cell-mediated antigen presentation and induces antigen-specific t-cell responses, with the ability to induce apoptosis and necrosis [1].
更新時(shí)間:2025-09-05
SSE1806；化合物 SSE1806SSE1806
sse1806, a podophyllotoxin derivative (a natural antimitotic agent), functions as a microtubule/tubulin inhibitor, exhibiting potent anticancer and antiproliferative properties. it demonstrates a gi50 for inhibiting cancer cell growth between 1.29-21.15 μm. this compound induces mitotic disruption and g2/m phase arrest, upregulates p53 expression, and suppresses the growth of colon cancer organoids. notably, sse1806 can counteract multidrug resistance in cell lines that overexpress mdr-1 [1].
更新時(shí)間:2025-09-05
PK-10；化合物 PK-10PK-10
pk-10, when combined with fluconazole, exhibits potent synergistic antifungal activity against multiple fluconazole-resistant candida albicans strains. this compound impedes hyphae formation, stimulates reactive oxygen species accumulation, and inflicts mitochondrial membrane potential damage. consequently, pk-10 decreases cellular atp levels and induces mitochondrial dysfunction [1].
更新時(shí)間:2025-09-05
8-Amino-1-Naphthalenesulfonic Acid；周位酸8-Amino-1-Naphthalenesulfonic Acid
8-amino-1-naphthalenesulfonic acid is a naphthalene derivative used as a fluorescent dye and as a reagent in organic synthesis. it is a highly fluorescent compound with a high stokes shift, making it an ideal fluorescent marker for a wide range of biological systems.
更新時(shí)間:2025-09-05
PI3Kα/HDAC6-IN-1；化合物 PI3Kα/HDAC6-IN-1PI3Kα/HDAC6-IN-1
pi3kα/hdac6-in-1 (compound 21j) is a dual inhibitor of pi3kα and hdac6, exhibiting ic50 values of 2.9 nm and 26 nm, respectively. it effectively hinders akt(ser473) phosphorylation and promotes the build-up of acetylated α-tubulin, while not influencing acetylated histones h3 and h4. the compound demonstrates potent anti-cancer efficacy by inhibiting the l-363 cell line with an ic50 of 0.17 μm [1].
更新時(shí)間:2025-09-05
H-Asp(AMC)-OH；化合物 H-Asp(AMC)-OHH-Asp(AMC)-OH
h-asp(amc)-oh, an amino acid derivative and fluorescent dye, does not inhibit glycine transport at a concentration of 0.25 mm [1].
更新時(shí)間:2025-09-05
HAPSBC；化合物 HAPSBCHAPSBC
hapsbc, an s-benzyl iron chelator, modulates the intracellular distribution of ^59fe [1].
更新時(shí)間:2025-09-05

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